Female Harlequin Great Dane Puppies for sale

19 Puppies found

The Great Dane is often called the “gentle giant” of the dog world, admired for its towering stature and calm, affectionate personality. Descended from ancient Molossus war dogs and refined in Germany to hunt wild boar, the breed later became a symbol of elegance and nobility. With their sleek, muscular build, graceful posture, and loyal temperament, Great Danes combine regal appearance with a sweet, patient nature that makes them beloved family companions.

Despite their massive size, Great Danes are gentle, friendly, and eager to please. They thrive on human companionship and are known for being affectionate with children and sociable with other pets. Protective when needed but never aggressive, they make excellent watchdogs as well. Their short coat requires only weekly brushing, and moderate daily exercise keeps them healthy and happy. With their kind spirit and noble presence, Great Danes bring both majesty and warmth to any home.

Great Dane dogs Pearl Great Dane - Ad 1

Great Dane dogs Pearl Great Dane - Ad 2

Pearl Great Dane

Great Dane

Pearl is a harlequin female Great Dane puppy raised with thoughtful care, early socialization, and gentle handling to support healthy development. She receives daily interaction and thoughtful develop

Greens Fork, IN

Great Dane dogs Great Dane 3 - Ad 1

Great Dane dogs Great Dane 3 - Ad 2

Great Dane 3

Great Dane

She's going to be a beauty and will love being wherever you are.

Great Dane dogs Cherish Great Dane - Ad 1

Great Dane dogs Cherish Great Dane - Ad 2

Cherish Great Dane

Great Dane

Meet Cherish, a harlequin female Great Dane puppy raised in a loving environment with early socialization and hands-on care from day one. She receives daily interaction and thoughtful development to h

Great Dane dogs Sparkler - Ad 1

Great Dane dogs Sparkler - Ad 2

Sparkler

Great Dane

Sparkler is a Great Dane puppy. -LancasterPuppies

Crystal River, FL

Great Dane dogs Savannah - Ad 1

Great Dane dogs Savannah - Ad 2

Savannah

Great Dane

Blue Merle Female

Middleborough, MA

Great Dane dogs Penelope - Ad 1

Great Dane dogs Penelope - Ad 2

Penelope

Great Dane

Black Coat with white chest & back feet. Penelope is a sweetheart, laid back personality, attentive and eager to be right next to you. She enjoys her stuffy toys, chewies, & all the cuddling. S

Great Dane dogs Harlequin Merle - Ad 1

Great Dane dogs Harlequin Merle - Ad 2

Harlequin Merle

Great Dane

Welcome to Dynasty Danes, home of beautiful, quality, AKC Great Danes. We have been enjoying and breeding our Danes for over 20 years. We specialize in Harlequins, Blues, Blacks and Fawns. All puppies

Great Dane dogs Dakota - Ad 1

Great Dane dogs Dakota - Ad 2

Dakota

Great Dane

Blue Mantle Female

Middleborough, MA

Great Dane dogs Montana - Ad 1

Great Dane dogs Montana - Ad 2

Montana

Great Dane

Black Mantle Female

Middleborough, MA

Great Dane dogs Cheyenne - Ad 1

Great Dane dogs Cheyenne - Ad 2

Cheyenne

Great Dane

Black Female

Middleborough, MA

Great Dane dogs Moxie - Ad 1

Great Dane dogs Moxie - Ad 2

Moxie

Great Dane

Harlequin female Moxie is a precious pup! She is very lovable, playful and inquisitive. She is eager to please, quick to respond to you & is a cuddle puppy. This sweet girl will make a perfect add

Great Dane dogs Cassidy - Ad 1

Great Dane dogs Cassidy - Ad 2

Cassidy

Great Dane

Black Female

Middleborough, MA

Great Dane dogs Great Dane 3 - Ad 1

Great Dane dogs Great Dane 3 - Ad 2

Great Dane 3

Great Dane

Blue Harlequin

Westborough, MA

Great Dane dogs Diva Denise - Ad 14

Diva Denise

Great Dane

Diva Denise has a black coat with some small white markings on her chest and rear toe. She is a sweet puppy and is looking for a family to love her. Misty welcomed 10 beautiful, healthy puppies int

Newberry Township, PA

Great Dane dogs Makani - Ad 15

Makani

Great Dane

Makani is the prettiest harlequin. She is super curious and an all around happy girl.

Great Dane dogs Xenia - Ad 16

Xenia

Great Dane

Xenia has a solid black coat. She was the first born on this litter and wants to be part of your pack. Misty welcomed 10 beautiful, healthy puppies into the world on July 18, 2026. 7 females and 3

Newberry Township, PA

Great Dane dogs Zoey - Ad 17

Zoey

Great Dane

I am Merle I am easy going. Eager to please I am sweet and noble I am a Big cuddle buddy. I am a big Lap dog. I cost more with Registration Papers

Great Dane dogs Luna - Ad 18

Luna

Great Dane

I am Merle I am easy going. Eager to please I am sweet and noble I am a Big cuddle buddy. I am a big Lap dog. I cost more with Registration Papers

Great Dane dogs Mabel - Ad 1

Great Dane dogs Mabel - Ad 2

Mabel

Great Dane

Mabel is a smoky fawn color with black mask. She is a sweetheart. She loves to cuddle, run and play tug of war. Mabel has a calm & confident disposition & is ready to find a home with the perfect pe

FAQs

The average cost of a purebred Great Dane puppy in the United States is approximately $1433, though prices can vary based on factors such as pedigree, breeder reputation, and location.