The Boxador is generally a robust cross, but it can inherit the documented conditions of either parent, so buyers should know both breeds' OFA/CHIC testing schemes.
From the Boxer side, the most important concern is heart disease. Arrhythmogenic right ventricular cardiomyopathy (ARVC), often called Boxer cardiomyopathy, is an adult-onset rhythm disorder that can cause collapse or sudden death; the American Boxer Club's CHIC protocol calls for annual Holter monitor screening and the ARVC (striatin) DNA test. Boxers are also screened for aortic/subaortic stenosis (AS/SAS) via a cardiologist exam, degenerative myelopathy (DM) by DNA test, hip dysplasia, and thyroid disease. Boxers additionally carry elevated rates of certain cancers, particularly mast cell tumors and lymphoma, which has no pre-breeding test — another reason longevity in the parent lines matters.
From the Labrador side, the CHIC scheme requires OFA hip and elbow evaluations, an annual eye exam by a board-certified ophthalmologist, the Exercise-Induced Collapse (EIC) DNA test, and the PRA-prcd DNA test for progressive retinal atrophy; centronuclear myopathy (CNM) testing is optional. Labradors are also strongly prone to obesity, which a Boxador can inherit along with the appetite.
Conditions relevant from both parents include hip and elbow dysplasia, hypothyroidism, and allergies. Both breeds are deep-chested, so gastric dilatation-volvulus (bloat) is a genuine emergency risk: feed measured meals, avoid heavy exercise right after eating, and learn the symptoms (unproductive retching, distended abdomen, restlessness). The Boxador's muzzle is usually longer than a purebred Boxer's, which reduces — but does not always eliminate — brachycephalic heat sensitivity; use caution exercising in hot, humid weather. With tested parents, sensible feeding, and adequate exercise, a Boxador can be expected to live roughly 10 to 14 years.