A first-generation cross draws its health risks from both parents, and both the Great Dane and the Standard Poodle carry serious, named conditions. Hybrid vigor may help — the cross's typical 8-12 year lifespan is meaningfully longer than the Great Dane's 8-10 — but it is no guarantee.
From the Great Dane side, the headline risk is gastric dilatation-volvulus (GDV or bloat), where the stomach fills with gas and twists. Great Danes are the highest-risk breed of all — research has put their lifetime risk near 40% — and any deep-chested Danoodle inherits substantial risk. It is a life-threatening emergency: know the signs (unproductive retching, swollen abdomen, restlessness) and discuss preventive gastropexy with your vet. Dilated cardiomyopathy (DCM), a progressive heart-muscle disease that can cause sudden death, is the Great Dane's other major problem — ask for a recent echocardiogram (OFA Advanced Cardiac evaluation) on the Dane parent. Hip dysplasia affects both parent breeds and is screened in the United States through OFA hip evaluations; given the cross's weight, keep adults lean and restrict puppy exercise.
From the Standard Poodle side come progressive retinal atrophy (PRA) — incurable, progressive blindness for which the prcd-PRA DNA test is available — plus sebaceous adenitis (an inflammatory skin disease causing hair loss and scaling, screened by skin biopsy), Addison's disease (underactive adrenal glands, treatable once diagnosed) and bloat again, as Standard Poodles are themselves a deep-chested at-risk breed. Entropion (inward-rolling eyelids) is reported in the cross and is picked up by an annual CAER eye examination.
Insure from day one at giant-breed premium levels, and buy only from litters where the parents' OFA results and DNA tests are documented — with no registry oversight of the cross, those certificates (ideally a CHIC number on both parents) are the only quality control available.