OFA hip evaluation, SAS cardiac screening (the Newfoundland parent's most specific condition), PRA DNA (Standard Poodle parent), Cystinuria DNA (Newfoundland parent), and CAER eye examination are the comprehensive health testing baseline. Bloat/GDV is the most acute safety concern — two daily meals (never one large meal), no vigorous exercise for an hour before or after eating, and owner awareness of early bloat symptoms (unproductive retching, distended abdomen, restlessness after eating) are non-negotiable management steps. Lifespan 8-12 years typically; some individuals exceed this.